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Copper transport drug restores memory and clears toxic Alzheimer's proteins (🔥 Score: 151+ in 3 hours)
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Monash University
Copper drug restores memory and clears toxic Alzheimer’s proteins
Monash University researchers have found in laboratory experiments that a drug which delivers copper to the brain significantly reduces toxic Alzheimer’s proteins and improves long-term spatial memory.
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Typst 0.15.0 (🔥 Score: 151+ in 2 hours)
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Typst
0.15.0 - Typst Documentation
Changes in Typst 0.15.0
梵高向日葵花型对称性的遗传分析揭示菊科中 CYCLOIDEA 基因的独立募集
Mark A. Chapman, Shunxue Tang, Dörthe Draeger, Savithri Nambeesan, Hunter Shaffer, Jessica G. Barb, Steven J. Knapp, John M. Burke
https://doi.org/10.1371/journal.pgen.1002628
摘要
花型对称性的遗传基础是一个备受关注的课题，因为它直接影响传粉者行为，进而对植物多样化产生深远影响。菊科是被子植物中最大的科，是研究这一性状的理想体系——该科许多物种具有复合花序，同时包含两侧对称（即左右对称型）和辐射对称（即辐射型）两种小花。在向日葵及其近缘种中，花序由单轮舌状花围绕多轮管状花组成。
我们发现，在重瓣（dbl）向日葵突变体中（管状花发育出两侧对称形态），如文森特·梵高在其19世纪著名向日葵画作中所描绘的那种花型，一个 CYCLOIDEA（CYC）类基因（HaCYC2c）的启动子区域发生了插入突变——该基因在野生型中仅在舌状花中特异性表达，而在突变体中却遍及整个花序表达，由此推测导致了辐射对称性的丧失。同一基因在两个独立的管状舌状花（tub）突变体中也发生了突变，但这些突变涉及明显的近期转座子插入，导致该基因几乎不表达或完全不表达，使原本两侧对称的舌状花发生辐射化。
值得注意的是，对全科 CYC 类基因的系统发育分析表明，这一引人入胜的基因家族中的不同旁系同源基因，在菊科不同物种中被独立募集，分别参与两侧对称性的形成。
Mark A. Chapman, Shunxue Tang, Dörthe Draeger, Savithri Nambeesan, Hunter Shaffer, Jessica G. Barb, Steven J. Knapp, John M. Burke
https://doi.org/10.1371/journal.pgen.1002628
摘要
花型对称性的遗传基础是一个备受关注的课题，因为它直接影响传粉者行为，进而对植物多样化产生深远影响。菊科是被子植物中最大的科，是研究这一性状的理想体系——该科许多物种具有复合花序，同时包含两侧对称（即左右对称型）和辐射对称（即辐射型）两种小花。在向日葵及其近缘种中，花序由单轮舌状花围绕多轮管状花组成。
我们发现，在重瓣（dbl）向日葵突变体中（管状花发育出两侧对称形态），如文森特·梵高在其19世纪著名向日葵画作中所描绘的那种花型，一个 CYCLOIDEA（CYC）类基因（HaCYC2c）的启动子区域发生了插入突变——该基因在野生型中仅在舌状花中特异性表达，而在突变体中却遍及整个花序表达，由此推测导致了辐射对称性的丧失。同一基因在两个独立的管状舌状花（tub）突变体中也发生了突变，但这些突变涉及明显的近期转座子插入，导致该基因几乎不表达或完全不表达，使原本两侧对称的舌状花发生辐射化。
值得注意的是，对全科 CYC 类基因的系统发育分析表明，这一引人入胜的基因家族中的不同旁系同源基因，在菊科不同物种中被独立募集，分别参与两侧对称性的形成。
journals.plos.org
Genetic Analysis of Floral Symmetry in Van Gogh's Sunflowers Reveals Independent Recruitment of CYCLOIDEA Genes in the Asteraceae
Author Summary The evolution of flower shape and symmetry is of great interest to plant biologists, because it can affect pollinator behavior. Species in the flowering plant family Asteraceae exhibit flower heads that can contain both bilaterally and radially…
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Stop Killing Games fails to secure EU law despite 1.3M signatures (Score: 157+ in 5 hours)
Link: https://readhacker.news/s/6WycJ
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Dexerto
Stop Killing Games fails to secure EU law despite 1.3M signatures - Dexerto
The Stop Killing Games campaign has been dealt a major setback after the EU declined to force publishers to keep discontinued games playable.
😢7
Julien Chaumond:
https://twitter.com/julien_c/status/2067218800164884594
https://twitter.com/julien_c/status/2067218800164884594
etn.:
BREAKING: Anthropic’s Dario Amodei, OpenAI’s Sam Altman, DeepMind’s Demis Hassabis and Mistral’s Arthur Mensch will meet for a 2-hour lunch today, per politico.
https://twitter.com/etnshow/status/2067187282075861343
😁1