This new tool allows scientists to watch DNA damage and repair unfold in real time inside living cells ... Other laboratories contacted them even before publication, eager to use the sensor in their own research on DNA repair.
In most mammals, cGAS interferes with DNA repair, but the researchers suspected it may have evolved a different function in the long-living rats ... DNA repair and delays aging, Science (2025).
"We've cracked the code on how plants stay virtually ageless under high UV exposure – which causes 80% of aging – with compounds that allow them to repair UV-caused DNA damage daily.
A pathway known for repairing damaged genetic material, called the ATM-gH2av pathway, gets repurposed and ... They found that genes linked to the DNA-repair pathway lit up only in response to pathogens.