ONNVF), (profile) a Canadian clinical-stage oncology company developing ONC010(TM), a nanoparticle-encapsulated PNKP inhibitor that targets a DNA repair enzyme involved in multiple DNA repair pathways.
This discovery links MINDY3 to the RAD23–proteasome axis, guiding MINDY3 to sites where DNA damage has occurred and suggesting a coordinated role in protein quality control during DNA repair processes ... MINDY3 at the site of DNA repair.
) This graphical abstract illustrates multiple phases of the DNA repair process carried out by high-resolution structures captured with cryogenic electron microscopy ...Best snapshots yet of DNA repair protein relevant to BRCA mutations.