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) Glenmark Secures Exclusive Multi-Regional Rights to Aumolertinib, an MHRA and NMPA approved Third-Generation EGFR-TKI, from Hansoh Pharma ... China-developed EGFR-TKI to be launched internationally.
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... kinase inhibitor (TKI) ... The ongoing global, single arm, open label Phase 2 portion is designed with registrational intent for TKI-naïve and TKI pre-treated patients with advanced ROS1-positive NSCLC.
In 253 ALKTKI pre-treated patients, ORR by BICR was 31% (95% CI. 26, 37), with initial estimated durability of response of 64% and 53% at the 12-month and 18-month landmarks, respectivelyIn the subset of 63 TKI pre-treated patients who ....
In 253 ALKTKI pre-treated patients, ORR by BICR was 31% (95% CI ...EfficacyAnalysis in TKI Pre-treated Advanced ALK-positive NSCLC ... Of the overall TKI pre-treated population, 25% (63/253) of patients were lorlatinib-naïve ... TKI Pre-treated,.
Nuvalent Announces Positive Topline Pivotal Data from ALKOVE-1 Clinical Trial of Neladalkib for TKI Pre-treated Patients with Advanced ALK-positive NSCLC In 253 ALK TKI pre-treated patients, ORR by BICR was 31% (95% CI ... Any prior ALK TKI.
ET, to discuss topline pivotal data for neladalkib, an investigational ALK-selective inhibitor, in TKI pre-treated patients with advanced ALK-positive non-small cell lung cancer from the global ALKOVE-1 Phase 1/2 clinical trial.
... (TKI) therapy ... Consistent PFS and OS benefits were observed across all prespecified subgroups, including prior EGFR-TKI therapy, presence of liver or brain metastases, and EGFR mutation subtype.