CLE is the second indication InnoCare is developing for ICP-488, and enrollment for the phase III study of ICP-488 for psoriasis is nearing completion ... .
The current indications under development are strategically positioned within the vast dermatology market, including AD, vitiligo, PN, CSU, and more ... .
GLPG3667 met primary endpoint in dermatomyositis study, demonstrating a statistically significant clinical benefit and meaningful improvements on secondary measures of disease activity compared to placebo ... .
LNK01006 is a highly brain-penetrant, potent, and selective oral TYK2 allosteric inhibitor targeting the JH2 domain. TYK2 is a key regulator of the IL-12 and IL-23 signaling pathways, which promote Th1 and Th17 cell differentiation.
The data show that the in vitro pharmacological profile of GLPG3667 suggests differentiation from other TYK2 inhibitors at their clinical dose regimens ... Zasocitinib showed the most sustained inhibition of TYK2-dependent pathways.