Antibodies inherit their structure from the genetic Ig germline locus. The exact physical structure of the antibody is determined by the genetic predispositions of the patient, which is why one ...

Integral Molecular Uses Shotgun Mutagenesis to Germline-Humanize Monoclonal Antibodies Seventy percent of FDA-approved monoclonal antibodies (mAbs) and approximately 66% of mAbs currently in ...

According to this study, the generation of antibodies is far from random because of germline-encoded amino acid–binding (GRAB) motifs.

A Phase 1 clinical trial provides promising results for a broadly neutralizing antibody (bnAb) HIV vaccine, according to a new study. The findings of this first-in-humans test establish a clinical ...

All bnAbs mature from a type of antibody-producing white blood cell, called a naive B cell. These B cells are often referred to as “germline” precursors.

In their related Perspective, Sanders and Moore add that the results provide a strong proof-of-concept for promising germline-targeting approaches, noting that the N332-GT5 trimer is now in a ...

A Phase 1 clinical trial provides promising results for a broadly neutralizing antibody (bnAb) HIV vaccine, according to a new study. The findings of this first-in-humans test establish a clinical ...

The vaccine candidate, dubbed eOD-GT8 60mer, uses a technique called "germline-targeting," which means that it was designed to induce broadly neutralizing antibodies by stimulating the body's ...

Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors. Immunity, 2022; DOI: 10.1016/j.immuni.2022.09.001 ...