Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By ...

This engineered amyloid beta vaccine, which the team have called TAPAS, was tested on mouse models of Alzheimer's disease, with the rodents indeed generating the associated antibodies in response.

This partner is a ring-shaped peptide that forms a short, antiparallel beta-sheet--known as a beta-hairpin structure--when it is bound to beta-catenin, as demonstrated by an analysis of its ...

The idea was to fix this cyclic peptide in the hairpin form by introducing an additional bridge. This generates a bicyclic structure that strengthens binding to beta-catenin.

First, they focused on AA residues 165, 169, 171, and 173 within the P168 beta-hairpin. In addition, they investigated the M pro helical region encompassing AA residues 45-49.

video: The structure of the hyperactive Type I antifreeze (Maxi) showing the extensive array of buried water molecules. The protein is a homodimer of beta-hairpin subunits (colored yellow and orange).

Methylation of elongation factor 1A by yeast Efm4 or human eEF1A-KMT2 involves a beta-hairpin recognition motif and crosstalks with phosphorylation.