The integrity of the c-kit signaling pathway is crucial for normal hematopoiesis, melanogenesis and gametogenesis (for a review see (Broudy, 1997)).Activation of this type III receptor tyrosine ...

The c-Kit’s significance as a therapeutic target is noted by the more than 40 FDA-registered clinical trials that investigate immunotherapies targeting c-Kit in cancer treatment.

The role of endogenous c-Kit receptor activation on cardiac cell homeostasis and repair remains largely unexplored. Transgenic mice carrying an activating point mutation (TgD814Y) in the kinase ...