MGTA-117 selectively targets CD117 (c-Kit) with a human monoclonal Ab to CD117 conjugated to an amanitin payload that depletes CD117-expressing cells by inhibiting RNA polymerase II. Human ...

The company expects to initiate a Phase 1 healthy volunteer clinical trial of BEAM-103, an anti-CD117 monoclonal antibody (mAb) designed to suppress hematopoietic stem and progenitor cells that ...