The 49ers likely have no intention of playing starter Christian McCaffrey in the preseason, backup Isaac Guerendo is out for ...

McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. With Isaac Guerendo ...

The 49ers may provide an indication of how they're feeling about their RB depth in the days ahead. If they sign another ...

The San Francisco 49ers cannot last more than a few months without losing their entire running back room to injury, even in the preseason. With multiple key players back on the shelf, the 49ers added ...

Mackenzie Brooks and the Inside the Lines Team break down where every NFC West team's season is most likely to end and how to ...

San Francisco's Christian McCaffrey revealed the unteachable traits that make 49ers QB Brock Purdy "so special." ...

The 49ers are hoping to rebound from a lost season in 2024 and Christian McCaffrey's return from injury will be a major boost ...

Christian McCaffrey has some dad guilt as football preseason heats up. The San Francisco 49ers running back has been busy in ...

Christian McCaffrey enters the 2025 season as a polarizing figure in fantasy football discussions. Despite his undeniable ...

Two top contenders this year face off in the preseason opener, with the San Francisco 49ers hosting the Denver Broncos. However, many fans are wondering whether stars Christian McCaffrey and Bo Nix ...