Background Chronic kidney disease is common in patients with coronary artery disease (CAD) and can significantly affect drug excretion and efficacy. This study focuses on the effects of modification ...

The blood-thinning drug clopidogrel is marketed under the brand name Plavix by Sanofi-Aventis and Bristol-Myers Squibb Co. . Lilly and Sankyo also said they are currently studying prasugrel in a ...

PARIS, France—New randomized data are crossing out a long-held hypothesis many assumed about how the potent antiplatelet agent ticagrelor works. Contrary to expectations, the drug does not appear to ...

Clopidogrel, prasugrel and ticagrelor: lack of data for network meta-analysis One drug manufacturer did not provide the requested additional data. However, exploratory analyses show that these ...

Clopidogrel, on the other hand, is reserved for patients who can’t tolerate ticagrelor/prasugrel or who require anticoagulation. Two Large Trials, Very Few Older Patients Speaking during the ESC ...

The rate of TIMI major or minor bleeding was statistically significantly greater with prasugrel than clopidogrel in the core group (3.9 percent vs. 3.0 percent respectively, p=0.033), but not in ...

(2) Wiviott, S.D. et al. Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes. New England Journal of Medicine 2007 Vol 357 (20); 2001-2015.

Electronic Medicines Compendium website. (3) Wiviott, S.D. et al. Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes. New England Journal of Medicine 2007 Vol 357 (20); 2001-2015.

Unlike clopidogrel and prasugrel, ticagrelor is not a thienopyridine, and its mechanism of action is "unique" in that it is reversible, Gurbel notes. And in phase 2 studies, "there was an efficacy ...

In addition to aspirin, patients were randomly assigned to a daily maintenance dose of prasugrel 5 mg (n = 713) or clopidogrel 75 mg (n = 730) from 2012 to 2017.

Mega explained to heartwire that both clopidogrel and prasugrel are prodrugs that require biotransformation to active metabolites by cytochrome (CYP) P450 enzymes, but that there appears to be a ...

Prasugrel vs. Plavix: The Handicapping Begins By Ron Winslow Nov. 5, 2007 8:56 am ET Resize ...