Thymidine kinase 2 (TK2) is a gene on chromosome 16. It's in a certain area on the long arm (q21) of the chromosome. It makes an enzyme (protein), TK2, to repair DNA inside your mitochondria.

Glucarpidase was administered at a median of 96 hours (receiving thymidine, n = 44) and 66 hours (not receiving thymidine, n = 56) after the start of the MTX infusion. Plasma MTX concentrations ...

UCB will contribute three presentations, including data on the disease course of thymidine kinase 2 deficiency (TK2d) in untreated patients and insights into caregiver impactThese data emphasize ...

The pharmacologic and clinical outcome of CPDG2 rescue administered with thymidine and leucovorin in 20 patients is presented here. Methods Patients with high-dose methotrexate-induced renal ...

Karaa, A., et al. Burden and impact of caring for those with thymidine kinase 2 deficiency (TK2d): results from the Assessment of TK2d Patient Perspectives (ATP) study. ©2025 UCB, Inc., Smyrna ...

Thymidine kinase 2 deficiency is an ultra-rare, life-threatening, genetic mitochondrial disease characterized by progressive and severe muscle weakness (myopathy), which can impact the ability to ...

Genomenon, a leader in genomic intelligence, today announced a strategic partnership with UCB to accelerate awareness, diagnosis, and research for thymidine kinase 2 deficiency (TK2d). Through ...

This study examined the relationship of thymidine phosphorylase expression in patients with advanced colorectal cancer to tumor response during 5-FU-based chemotherapy.

Suggested remit: To appraise the clinical and cost effectiveness of doxecitine–doxribtimine within its marketing authorisation for treating thymidine kinase 2 deficiency in people of any age.

UCB will contribute three presentations, including data on the disease course of thymidine kinase 2 deficiency (TK2d) in untreated patients and insights into caregiver impactThese data emphasize ...