CHRPE CHRPE is usually unilateral and asymptomatic, featuring a flat, variably pigment­ed lesion at the level of the RPE, often with depigmented lacunae and/or a depigmented halo.

Solitary congenital hypertrophy of the retinal pigment epithelium: clinical features and frequency of enlargement in 330 patients. Am J Ophthalmol. 2003;110 (10):1968-1976.

Congenital hypertrophy of the retinal pigment epithelium (CHRPE) is a benign disorder of the retinal pigment epithelium (RPE) classically described as flat, well-delineated, and with depigmented ...

Seventy-eight patients from 26 families were examined to evaluate the potentiality of congenital hypertrophy of retinal pigment epithelium (CHRPE) as a phenotypic marker for familial adenomatous ...