In spermatogenesis, loss of promoter DNA methylation reactivates retrotransposons in patterns shaped by chromatin ...

Development. 2024. Lenhart KF, Capozzoli B and DiNardo S. Failure of stem cell cytokinesis with age due to diminished JAK/Stat activity. Current Biology. 2019. Lenhart KF and DiNardo S. Somatic cell ...

The cells that make up non-germline tissues and organs are called somatic cells, which are not passed on to the next generation. Germline cells are special because they can become any cell type.

The cells that make up non-germline tissues and organs are called somatic cells, which are not passed on to the next generation. Germline cells are special because they can become any cell type ...

Researchers were able to retrace human development, including in a 78-year old individual, all the way back to the first cell division, as well as confirm that the mutation rate in the germline ...

Animals, from worms and sponges to jellyfish and whales, contain anywhere from a few thousand to tens of trillions of nearly genetically identical cells. Depending on the organism, these cells arrange ...

Evan Witt, Christopher B. Langer, Nicolas Svetec, Li Zhao. Transcriptional and mutational signatures of the Drosophila ageing germline. Nature Ecology & Evolution, 2023; DOI: 10.1038/s41559-022 ...

Germline cells, which pass on genetic material to the offspring, are of particular interest for genetic manipulation because any modifications made in the germline will be passed on to the entire ...

Experts once thought that germline cells might be ageless — somehow protected from the passage of time (SN: 3/10/04). But studies have shown signs of aging in eggs and sperm, dispelling that idea.

Researchers in Li Zhao ‘s lab studied mutations that occur during the production of sperm from germline cells, known as spermatogenesis. They found that mutations are common in the testes of ...