Thrombopoietin (TPO) is a hematopoietic growth factor which plays a central role in normal megakaryocytopoiesis and thrombopoiesis. Although the interaction between TPO and its receptor c-Mpl ...

Simplified JAK-STAT signaling pathway in megakaryocytes where hTPO activates the TPO receptor and triggers signaling cascades that stimulate platelet production (44, 45). Created with BioRender.com.

As Proof of Principle, Technique Finds Antibody that Mimics Key Hormone for Blood Clotting LA JOLLA, CA – May 23, 2013 – Scientists at The Scripps Research Institute (TSRI) have devised a ...

The mouse TPO receptor is almost identical to human TPO receptor, so Zhang was able to test his antibody agonist in mice.

It is designed to interact with the transmembrane domain of human TPO receptors to induce the proliferation and differentiation of megakaryocytic progenitor cells from hematopoietic stem cells and ...

The most powerful TPO agonist described in the study, antibody 3D9, performed much better in cell-culture tests—that is, required a much smaller amount to activate the TPO receptor on test cells ...

The mouse TPO receptor is almost identical to human TPO receptor, so Zhang was able to test his antibody agonist in mice.

Mulpleta is an orally bioavailable, small molecule TPO receptor agonist that interacts with the transmembrane domain of human TPO receptors expressed on megakaryocytes to induce the proliferation ...

The specific activity of GMP Human Thrombopoietin Protein is greater than 1.00 × 10 7 IU/mg, calibrated against the human TPO Standard (NIBSC code: 03/124) (QC tested).