In contrast, FcµR binding and C1q-medicated complement seemed unaffected by the integration of CD5L and IgM. CD5L occurred synchronously with IgM in circulation.

IGM Biosciences picked up $102 million in series C financing to work on its pipeline of cancer drugs, including a CD20- and CD3-targeting bispecific antibody slated to start clinical trials by the ...

Being stiff is an advantage, if it was floppy, it would not work so well. IgM, instead, assume three conformations: extended, bell and turtle shape".

Nonspecific IgM binding to erythrocytes infected by parasites expressing the PfEMP1 protein VAR2CSA (involved in placental malaria pathogenesis and protective immunity) blocked subsequent specific ...

Akhouri RR, Goel S, Furusho H, Skoglund U, Wahlgren M. Architecture of human IgM in complex with P. falciparum erythrocyte membrane protein 1. Cell Reports, 2016 DOI: 10.1016/j.celrep.2015.12.067 ...