CTSK is a key player in the bone resorption process. “So, we downregulate, reduce high expression of those [bone resorption] genes using the siRNA,” he says.

Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1α signaling. Bone Research, 2022; 10 (1) DOI: 10.1038/s41413-022-00225-w ...

The osteoblast communication via extracellular vesicles controls the dynamic transition from bone-forming to bone-resorbing phases in vivo and could be a target for new treatments for bone diseases.