This means that macrophages do not simply switch between the canonical two states previously described; instead, they can exhibit a mix of activation characteristics, reflecting the complexity of ...

Annals of the Rheumatic Diseases Source Reference: De Benedetti F, et al "Efficacy and safety of emapalumab in macrophage activation syndrome" Ann Rheum Dis 2023; DOI: 10.1136/ard-2022-223739.

Macrophage activation syndrome (MAS) is a severe complication of rheumatic diseases, most frequently in Still's disease including systemic juvenile idiopathic arthritis (sJIA) – a rare systemic ...

The effects of increasing concentrations of SARS-CoV-2 S on the activation of HLMs were evaluated in cell culture experiments, wherein human lung macrophages were stimulated with ...

“Our selective BRD4 (BD2) inhibitor, DC-9476, demonstrates a potentially new strategy to treat MAS by directly inhibiting macrophage activation,” said Kfir Schreiber, CEO & Co-Founder of DeepCure.

BMPPs can activate the M1 phenotype of macrophages, which can be used for immunotherapy against cancer. view more Credit: Na Kong from ShanghaiTech University ...