For example, they have characterized the transcriptome (mRNA, lncRNA, and miRNA) of aortas in an atherosclerosis mouse model, both during disease progression and after regression following treatment.

The 2024 Nobel Prize in Physiology or Medicine was jointly awarded to Victor R. Ambros, PhD, and Gary Ruvkun, PhD, for the discovery of microRNA and its role in gene regulation.The Nobel Assembly ...

Results. We identified six differentially expressed circRNAs in HCC, which were linked to 13 miRNAs and 88 mRNAs. A network containing 34 circRNA-miRNA pairs and 194 miRNA-mRNA pairs was constructed.

We identified twelve novel saliva and serum miRNAs and a panel of unique miRNA and mRNA signatures, significantly differentially expressed in saliva and serum of OSCC patients versus HC ...

When miRNA acts as the guide for RNAi, only a short part of the molecule, known as the seed region, pairs with the target, rather than the full ~20 nucleotide sequence. 1 This means miRNA guides can ...

The two compared findings and conducted additional research showing the lin-4 microRNA is responsible for turning off lin-14 by binding to the complementary sequences in its mRNA, blocking ...

One strand of the mature miRNA duplex, known as the guide strand, is incorporated into the RNA-induced silencing complex (RISC). The RISC, guided by the miRNA, binds to complementary sequences in the ...

Cerebral amyloid angiopathy (CAA) and insomnia are age-related neurological disorders increasingly recognized as being closely associated. However, research on the shared genes and their biological ...