Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...

Covalent bonds, in which two atoms are bound together by sharing a pair of electrons, form the scaffolding that underpins the majority of organic compounds. In 1931, the Nobel Laureate Linus ...

It described an unnatural amino acid that can turn a protein into a covalent binder (Cell 2020, DOI: 10.1016/j.cell.2020.05.028). “It was pretty clear to us both very early that this was a ...

Katherine Bourzac is a freelance journalist in San Francisco, California. For a little more than a century, chemists have known that strong atomic links called covalent bonds are formed when atoms ...