New data showed a survival advantage with newer chronic lymphocytic leukemia (CLL) treatments for older patients who are typically underrepresented in clinical trials.

Through this partnership, Metkinen achieved scale up of purine 3´-amino-2´,3´-dideoxyribonucleosides, required by Geron for its development-stage compound GERN163L, Michine states.

The purine analogs fludarabine, cladribine, and pentostatin are active agents in the treatment of indolent lymphoid malignancies. This report reviews the pattern, severity, and consequences of the ...

Cross-resistance between purine analogues does not necessarily occur, 69 and chemoimmunotherapy with a purine analogue plus rituximab leads to responses that are generally more durable than those ...

Recently published guidelines recommend purine analog monotherapy as first-line treatment and rituximab combined with purine analog for relapsed patients. 20, 21 The long-term efficacy and safety data ...

Compared with another naphthalene fused purine analogue (ND A, Fig. 3f), which exhibits non-planar structure and therefore emits poorly with a quantum yield less than 0.1, the strong fluorescence ...

The major disadvantage of triple combinations, including purine analogues is their hematologic toxicity. [13, 16, 30, 31] Since hematologic and immunosuppressive complications of nucleoside ...

Despite significant strides made in the prognosis of hairy cell leukemia (HCL) in recent decades— thanks to purine analogues like cladribine— a clear understanding of the underlying biology of ...

They noted that while the purine analogues cladribine and pentostatin have been the first-line therapy for hairy cell leukemia for over two decades (achieving complete remission rates in ...