New methods to shape RNA molecules into circles could lead to more effective and long-lasting therapies, shows a study by researchers at the University of California San Diego. The advance holds ...

The highly conserved stem-loop II motif is important for the lifecycle of astroviruses but dispensable for SARS-CoV-2; Andrew B Janowski, Hongbing Jiang, Chika Fujii, Macee C Owen, Traci L Bricker ...

First, RNA, the master switch. In neuronal stem cells, genes for the proteins that confer neural specificity are silenced. A key mediator of this cellular gag order is the neuronal restricted ...

With its acquisition of Subintro Ltd., Rigimmune Inc. put a building block in place to further its development of stem-loop RNA therapeutics that selectively activate the innate immune sensor RIG-I.

Aarhus University. "RNA regulation is crucial for embryonic stem cell differentiation." ScienceDaily. ScienceDaily, 19 November 2019. <www.sciencedaily.com / releases / 2019 / 11 / 191119105452.htm>.

Using a technique called RNA interference, they systematically shut down the function of each of more than 200 lincRNAs previously identified as playing a role in embryonic stem cells.

Figure 1: Overexpression of a 48-nt stem-loop structure in TLC1 interferes with telomeric silencing. a, The secondary structure of nt 288–335 in TLC1 RNA at 30 °C as predicted by mfold (ref. 30).

When infections occur in the body, stem cells in the blood often jump into action by multiplying and differentiating into mature immune cells that can fight off illness. But repeated infections ...