Whereas ATM signaling is well known to be activated by DNA doubles-strand breaks, this study provides new evidence that ATM signaling is directly activated by DNA single-strand breaks and ...

Led by Haichao Zhao, PhD, in the Yan Lab at UNC Charlotte, the new research shows how ATM-mediated signaling is induced by DNA single-strand breaks (SSBs) for DNA damage repair – illuminating ...

In the new study, published today in Nature Communications, researchers demonstrate their use of plasmid-based SSB structures to examine APE1's critical role in DNA damage response (DDR) signaling ...