Their findings confirmed earlier observations that lincRNA expressions were far more dependent on the tissues that contained them than messenger RNA expressions.

That comparison yielded 47 lincRNA transcripts, of which the team selected the most prevalent 14. They then checked how these lincRNAs were expressed by 12 established breast cancer cell lines and ...

Higher levels of the molecule called HOTAIR silenced genes that usually suppress metastasis, as reported in Nature. A group of researchers have figured out how levels of a specific long ...

A long non-coding RNA (lincRNA) -- called lincRNA-EPS -- responsible for regulating innate immunity has been identified by a team of scientists. This discovery points to an unrecognized role for ...

Furthermore, lincRNA-p21 expression in response to DNA damage was significantly attenuated in cells lacking ING1b. LincRNA-p21 is also a target of p53 and can trigger apoptosis in mouse cell models.

Ever since the Human Genome Project decoded the genome, the prevailing scientific view has been that only the 2 percent that makes proteins—the building blocks of cells—was important. The rest ...

LincRNA-Cox2 can inhibit some genes and enhance the expression of others. Previous work by Carpenter’s lab and others had shown these effects in cell cultures, but the new study used genetically ...

This long intergenic noncoding RNA (lincRNA) modulates the levels of transcription factor FOXP3 and the suppressive function of human regulatory T cells by controlling the interleukin-2 receptor.

Our genetic code includes over 15,000 specific sections that can be made into molecules called lincRNAs. Some of these sections can occur in coiled-up sections of our genome called TADs. LincRNAs ...

Once considered part of the "junk" of our genome, much of the DNA between protein-coding genes is now known to be transcribed. New findings by scientists at Fox Chase Cancer Center have identified ...