1660s, "deteriorated condition, state of being degenerate;" 1670s, "tendency to decrease in excellence of essential qualities, a downward course;" see degenerate (adj.) + abstract noun suffix -cy.

"tending to degenerate," 1846; see degenerate + -ive.

active word-forming element in English and in many verbs inherited from French and Latin, from Latin de "down, down from, from, off; concerning" (see de), also used as a prefix in Latin, usually meaning "down, off, away, from among, down from," but also "down to the bottom, totally" hence "completely" (intensive or completive), which is its sense in many English words.

As a Latin prefix it also had the function of undoing or reversing a verb's action, and hence it came to be used as a pure privative — "not, do the opposite of, undo" — which is its primary function as a living prefix in English, as in defrost (1895), defuse (1943), de-escalate (1964), etc. In some cases, a reduced form of dis-.

*genə-, also *gen-, Proto-Indo-European root meaning "give birth, beget," with derivatives referring to procreation and familial and tribal groups.

It might form all or part of: Antigone; autogenous; benign; cognate; congener; congenial; congenital; connate; cosmogony; cryogenic; degenerate; engender; engine; epigone; eugenics; -gen; gendarme; gender; gene; genealogy; general; generate; generation; generic; generous; genesis; -genesis; genial; -genic; genital; genitive; genius; genocide; genotype; genre; gens; gent; genteel; gentile; gentle; gentry; genuine; genus; -geny; germ; german (adj.) "of the same parents or grandparents;" germane; germinal; germinate; germination; gingerly; gonad; gono-; gonorrhea; heterogeneous; homogeneous; homogenize; homogenous; impregnate; indigenous; ingenious; ingenuous; innate; jaunty; kermes; kin; kindergarten; kindred; king; kind (n.) "class, sort, variety;" kind (adj.) "friendly, deliberately doing good to others;" Kriss Kringle; malign; miscegenation; nada; naive; nascent; natal; Natalie; nation; native; nature; nee; neonate; Noel; oncogene; ontogeny; photogenic; phylogeny; pregnant (adj.1) "with child;" primogenitor; primogeniture; progenitor; progeny; puisne; puny; renaissance; theogony; wunderkind.

It might also be the source of: Sanskrit janati "begets, bears," janah "offspring, child, person," janman- "birth, origin," jatah "born;" Avestan zizanenti "they bear;" Greek gignesthai "to become, happen," genos "race, kind," gonos "birth, offspring, stock;" Latin gignere "to beget," gnasci "to be born," genus (genitive generis) "race, stock, kind; family, birth, descent, origin," genius "procreative divinity, inborn tutelary spirit, innate quality," ingenium "inborn character," possibly germen "shoot, bud, embryo, germ;" Lithuanian gentis "kinsmen;" Gothic kuni "race;" Old English cennan "beget, create," gecynd "kind, nature, race;" Old High German kind "child;" Old Irish ro-genar "I was born;" Welsh geni "to be born;" Armenian cnanim "I bear, I am born."