Human Nature: Die CRISPR Revolution

Balance is a word we take for granted. It is as hard to achieve in film as it is easy to grasp conceptually. This is a balanced film.

It is also beautifully shot, scored, edited... I am looking forward to the directors 2nd piece!?

Personally, I have been hosting the intuition that there is a non-benign (read, potentially fatal) shortage of sagacity in our species. This is most evident in our relationship with technology. So throughout the film I was waiting, pleading for someone to say a thing. And when the youth with sickle cell, a few moments before the curtain, says it, my heart leaped at him. We suffer for a reason.

Ask the right question. Do we want to stop suffering?

My Rating : 8/10

Super informative but also a very fun watch! The documentary delves into the crux of human advancement in eugenics and the balance of greed required to actualise it's dignified success.

Gene-editing is a future we as a species must learn to adopt skilfully so that mankind can smoothly transition to the next century and beyond.

A serene documentary - important messages throughout. Good humour too!

Well made movie which features some of the pioneers of the field, unlike some random guy from Youtube who made a video after reading some blog off the internet. CRISPR is the next internet & what we know about it & its uses is just the tip of the iceberg. The movie goes on tell the positives & negatives of gene editing but a viewer can't visualise the best & worst ways in which this can be used. I feel that it could have been a bit more dramatic and with a little more information it would have been the go to documentary for CRISPR related knowledge.

Even if you are not familiar with science and biology, Human Nature does an excellent job at explaining how gene editing and everything work. From the origins of the method to its application, they try to be as neutral as possible, weighing the pros and cons. Every person interviewed is asked about the potential benefits but also dangers of this new method.

Greetings again from the darkness. That feeling when you start up a 95 minute documentary and a black and white clip of a Biologist giving a speech in 1966 fills the screen ... it's a moment of dread, which fortunately, filmmaker Adam Bolt quickly turns into a fascinating education. The fellow giving the 1966 speech (I missed his name) states that someday we will be able to alter human genes. More than 50 years later, Mr. Bolt's film shows us that scientists are beyond that, and on the verge of developments that demand some serious and literally life-altering discussions.

Deep science and cinematic story-telling aren't typically a good mix, but here we have a blending of journalists, researchers, and many types of scientists working with a knowledgeable filmmaker. They succeed in explaining the 'why' and 'what for' of gene-editing in a way that even a simpleton such as yours truly could follow. Going in, the concept of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) was vague at best (for me), and those involved with the film explain how this has opened the scientific door to the building blocks of life through gene-editing.

For structure, the film is divided into six chapters: Needle in a Haystack, CRISPR, The Gene Machine, Brave New World, The Good Gene, and Playing God. These chapters touch on the story of young David Sanchez (afflicted with Sickle Cell Anemia), food and bacteria, Aldous Huxley's book, eugenics, and morality. With so much to cover, the film excels in providing just enough for viewers, and putting the spotlight on those who can best explain their area of expertise or what results might mean.

Science often complements humanity while simultaneously standing opposed to nature. The film even shows the infamous JURASSIC PARK clip where Dr. Ian Malcolm (Jeff Goldblum) tries to confront the idea of genetic altering by stating, "Scientists were so preoccupied with whether or not they could, they didn't stop to think if they should." There are also clips from BLADE RUNNER and GATTACA, and they all lead us to the question on everyone's mind ... should we play God? Most agree that stopping genetic diseases is a worthy goal, but how about designer babies? That's where discussion of Huxley's "Brave New World" and Hitler come in. Should we be architecting the "perfect human being"? When Dr. Jennifer Doudna asks, "What have I done?", she's smiling on the outside as a scientist, but surely has doubts as a person.

Keegan DeWitt's score is top notch for a documentary, but a film about isolating individual and specific strands of DNA isn't really about style. Listening to bioengineers discuss their own work and that of others in the field, gives us the basics of the science involved; however, as a society we must come to grips with that big question. Do we play the hand we're dealt, or do we stack the deck and keep one up the sleeve? At some point very soon, we must decide. As the film states, after 2 billion years, this is the end of the beginning. What does the next stage look like?