Marques Houston officially left the show after season 5 because his mother died. He returned to appear in Fly Away Home (1999), the series finale.
Jackée Harry and Tim Reid would later play husband and wife in the Lifetime television movie Weihnachten in Alaska (2018). Tia Mowry played their daughter in the same film.
Tamera Mowry-Housley's and Tia Mowry's real-life brother Tahj Mowry guest starred in three different episodes, each time as a different character.
At the beginning of the show's run, a beauty mark was drawn on Tia Mowry's cheek to match the natural one on Tamera Mowry-Housley's cheek.
Celebrities who had made appearances throughout the series included Milton Berle, Boyz II Men, Kobe Bryant, Tyrese Gibson, Sherman Hemsley, Lisa Leslie, Kel Mitchell, Brittany Murphy, Ashley Olsen, Mary-Kate Olsen, Daphne Reid, Molly Shannon, and Kenan Thompson.