David Kaufman voices a character originally played by Michael J. Fox. He previously stood in for Fox in Zurück in die Zukunft (1991).
The biological Little children have the same names as the HBO hippos.
With the exceptions of Hugh Laurie, Jeffrey Jones and Marc John Jefferies none of the actors from the films they repeat roles.
Both Kevin Schon and Quinton Flynn replace Nathan Lane as the voice of Snowbell in the series. Both actors had previously replaced Lane as the voice of Timon in the Abenteuer mit Timon und Pumbaa (1995), while Schon is known to serve as Lane's voice double in other projects.