The Driller was composed of 70,000 pieces. It required ILM to use up its entire render farm, and took 122 hours per frame (288 hours in the Driller's attack on the skyscraper).
According to Michael Bay, 532 vehicles were destroyed in the film. They were given away by an insurance company, at no charge, as all of them were flood-damaged.
(at around 27 mins) Peter Cullen's favorite moment in the film is when Optimus Prime meets with astronaut Buzz Aldrin.
Sentinel Prime was originally meant to be colored yellow-gold, but as fire trucks are a standard red, he had to be re-colored at an expense of several thousands of dollars.
(at around 24 mins) Michael Bay swore that the Autobot Twins, Skids and Mudflap, would not be in the film, and promised 25,000 dollars to whomever could spot them. However, they do appear in one scene: when Director Mearing arrives at NEST.
Maile Flanagan: (at around 39 mins) the Naruto (2002) voice actor can be seen in the elevator with Sam Witwicky when Deep Wang first encounters him.