A film director (Margherita Buy), in the middle of trying to do a film, has to deal with the fact that her mother is dying.
The film is inspired by the death of Nani Moretti's own mother, and we can assume that the Buy character represents him, as a movie director dealing with a difficult production, a temperamental and looney actor (John Turturro), and a terminally-ill mother she keeps telling herself is going to recover.
Anyone who has been through this life-goes-on in the face of tragedy scenario will relate to the director trying to deal with her ex-husband, her daughter, her boyfriend, her mother, and the movie - all at the same time. It's a very human story. Unfortunately you can't pick when a crisis will occur, or expect them to come one at a time.
Wonderful acting, especially Buy as her character, Margherita, tries to keep it all together as her leading man, an American who knows Italian, can't remember his lines, the extras all look like movie stars when she asked for normal everyday people, all the while visiting her mother at the hospital and being in denial about her illness.
Very good film.