- On September 16, 1968, she was severely injured in an automobile accident, resulting in memory loss and nightmares. She was admitted to a state mental hospital at age 17 but left after less than a year.
- Owns and operates a 50-acre macadamia-nut farm in Hawaii where she and her partner keep beehives, goats, and a lone black sheep named Roseanne.
- Has a daughter from a previous relationship, Brandi Ann, whom she put up for adoption; years later she searched for her and was eventually reunited with her.
- States that she suffered from multiple-personality disorder.
- In 1994, she was the first female to host the annual MTV Music Awards.
- Had tubal ligation reversed in order to get pregnant with her son Buck.
- In a 1991 People magazine interview, she claimed to have been an incest survivor, accusing both parents of physical and sexual abuse, charges that they have publicly denied.
- Her daughters Brandi Brown, Jennifer Pentland, and Jessica Pentland all worked with her on her talk show.
- On Friday, August 23, 1985, she made her national television debut on The Tonight Show Starring Johnny Carson (1962). This marked the turning point in her career, and she was deluged with job offers thereafter.
- Her paternal grandfather was a Russian Jewish immigrant, and her paternal grandmother was born in Minnesota to Russian Jewish parents. Her maternal grandparents were Jewish emigrants from Austria-Hungary and Lithuania.
- Is a spokeswoman for various pro-choice groups, has asserted pro-choice views in publications such as "The Advocate", and has appeared at benefits sponsored by pro-choice organizations such as the Fund for a Feminist Majority. In several episodes of Roseanne (1988), Roseanne Conner defends a woman's right to choose.
- At age 17, she left Utah and moved to Denver, Colorado, where she gave birth to daughter Brandi Ann, then gave her up for adoption.
- Has three children with Bill Pentland: Jennifer Pentland, Jessica Pentland, and Jacob Pentland. Has one son with Ben Thomas: Buck Thomas.
- Ranked #9 in Comedy Central's 100 Greatest Stand-Ups of All Time, the highest-ranking woman.
- Unsuccessfully ran for president in the 2012 US election. She sought the Green Party presidential nomination, but finished second in the primaries to eventual nominee Jill Stein. She was later nominated for president by the Peace and Freedom Party and appeared on the ballot in California, Florida and Colorado. She received 67,326 votes and 0.05% of the popular vote, placing sixth overall. Her campaign was the subject of the documentary Roseanne for President! (2015).
- Renewed wedding vows with ex-husband and ex-bodyguard Ben Thomas on the 1999 Valentine's Day edition of her talk show. She first filed for divorce in January 1998, claiming he was an abusive binge drinker who threatened to kidnap their son. They finally divorced in October 2002.
- Worked as a dishwasher, cook, and waitress for Bennigan's Restaurant.
- Collects pigs.
- Gave birth to her first child at age 18, daughter Brandi Ann on 5/16/71 in Denver, Colorado. Child's father is unknown to the public and she was adopted by the Brown family.
- Worked as a guest-editor for the New Yorker magazine.
- She was unable to vote for herself during in the 2012 US presidential election, during which she was the nominee of the Peace and Freedom Party. She did not qualify for the ballot in Hawaii, her home state, which also does not allow write-in votes. She instead voted for President Barack Obama.
- Is played by Denny Dillon in Roseanne: retrato de una diosa (1994).
- Gave birth to her second child at age 22, daughter Jessica Lynn Pentland, on 3/18/75, by her first ex-husband, Bill Pentland.
- Attended Salt Lake High School East in Utah, but dropped out before graduating.
- She was awarded a Star on the Hollywood Walk of Fame for Television at 6767 Hollywood Boulevard in Hollywood, California on September 25, 1992.
- Gave birth to her fifth child at age 42, son Buck Thomas, in Los Angeles, California, on 8/5/95, by her third ex-husband, Ben Thomas.
- Is a heavy smoker.
- On 7/25/90, she sang the National Anthem at a baseball game between the San Diego Padres and Cincinnati Reds at Jack Murphy Stadium.
- Gave birth to her third child at age 23, daughter Jennifer C. Pentland on 5/28/76, by her first ex-husband, Bill Pentland.
- Biography in: "Who's Who in Comedy" by Ronald L. Smith. pg. 26-28. New York: Facts on File (1992). ISBN 0816023387.
- Gave birth to her fourth child at age 25, son James "Jake" Michael Pentland on 6/30/78, by her first ex-husband, Bill Pentland.
- Mentioned in the sitcom episode If Al Had a Hammer (1991).
- Born at 1:21 PM (MST).
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