- Earned a B.A. in Economics from Columbia University in 1978.
- Mother is German actress Maria Marx.
- His movie debut came when he was 12 in his father's 1971 film Violenta persecución (1971), where he had a love scene with an older woman.
- Son of director Melvin Van Peebles and German actress Maria Marx. Father of Maya Van Peebles, Marley Van Peebles, Mandela Van Peebles. Brother of Megan Van Peebles Max Van Peebles, Marguerite Van Peebles, and Makaylo Van Peebles.
- Mario appeared in the music video of Billy Joel's song "A Matter of Trust" in 1986.
- Was considered for the role of Detective Odafin 'Fin' Tutuola on Ley y orden: Unidad de Víctimas Especiales (1999).
- Has his own movie production company named "MVP Filmz".
- Chosen by People magazine as one of the 50 Most Beautiful People in the world. (1991)
- He is also the father of Morgana Van Peebles, with mother, Chittra Suku.
- Uncle of Ronald Van Jr. and Roman Van.
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