Not exactly, according to the press release, the game will feature an original story in which Nick Fury calls on heroes like the Avengers and X-Men to defeat villains like Loki and Galactus. However, some of the character's designs are based off of their movie counterparts.
According to the press release, there will be over 100 characters to unlock. It is confirmed that the Avengers, the X-Men, the Fantastic Four, Spider-Man, and Guardians of the Galaxy will appear.
