- Boyfriend of Julianne Hough [June 2010 - March 2013].
- Was a starting linesman on his high school football team.
- Was bitten by a small shark on July 28, 2008.
- In 2007, Forbes Magazine estimated his earnings for the year at $14 million.
- Attended the University of Georgia.
- In January 2004, he took over Casey Kasem's place as host of American Top 40. In December 2004, Ryan began hosting a second version of American Top 40 (Hot AC version).
- Had a very brief appearance as an extra in Marea roja (1995). He is shown as the submarine is getting underway, staring at an aquarium. He pointed this out himself when he was the host of NBC Saturday Night Movie (2000). Since he was an extra, he is not credited.
- Received a star on the Hollywood Walk of Fame for Radio at 6801 Hollywood Boulevard in Hollywood, California on April 13, 2005.
- Co-owns a Los Angeles sushi bar called Katana.
- Has mostly German and Swiss-German ancestry. He also has distant Irish roots. The family surname was originally spelled "Secrest".
- Has highly praised both Merv Griffin and Dick Clark for his stardom in television production.
- Resides in Los Angeles, California.
- Credits Merv Griffin as his favorite media mogul/best friend.
- Hosted the one-hour weekly radio program "Live from the Lounge" (2001-2002).
- Older brother of Meredith Seacrest.
- Former talk show host and legendary media mogul Merv Griffin took him under his wing, when Seacrest was 21. Their friendship lasted for a decade, until Griffin's own death in August 2007.
- Brother-in-law of James Leach.
- Son of Connie Seacrest and Gary Seacrest.
- One of People magazine's 50 Most Beautiful People in the World (2003).
- As an unfamilar television personality, he was mentored in the business by former talk show host and media mogul Merv Griffin. His first television exposure with Griffin, when Seacrest hosted the short-lived children game show, Click (1997).
- Uncle of Flora Leach.
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