- Spends every Thanksgiving with Helen Hunt.
- When he was a teenager, studied ballet with his childhood friend Eric Stoltz in Santa Barbara, California, so that "they could meet girls."
- When Edwards received a large bonus from the producers of ER, he donated a large portion of it to the Santa Barbara Junior High School for the renovation of its theater, later named in honor of his middle school drama teacher, Marjorie Luke. The Theater is now home to numerous plays and performances not only for the Junior High School, but also for the entire community.
- His grandfather designed Walt Disney Studios in the 1930s.
- Left his role in the 8th season of Sala de urgencias (1994) to spend more time with his family. Co-star, Noah Wyle did the same in the 10th season (though he has returned sporadically since).
- Plays basketball with friend George Clooney, who also co-starred with him on Sala de urgencias (1994).
- Was approached by Michael Crichton (author of "Jurassic Park") and producer John Wells to star in a two-hour pilot called Sala de urgencias (1994) after playing a lawyer in El cliente (1994).
- His ex-wife, Jeanine Lobell, is a respected & renowned make-up artist who also founded the Stila cosmetics line.
- Had a relationship with Meg Ryan [1986-1987].
- Owns his production company, Aviator Films
- Driver of Pace Car at 84th Indianapolis 500, May 28, 2000.
- Is currently on the Board of Cure For Autism Now Foundation.
- Has four children: Son Bailey (born June 1, 1994), daughters Esme and Wallis born (September 1, 2000) and daughter, Poppy (born March 15, 2002) with wife Jeanine Lobell.
- His parents wouldn't allow him to watch prime-time TV as a teenager.
- Is an honorary board member of Access Theatre, a repertory acting company comprised of disabled artists. A documentary he directed about this group has received several awards and is being distributed in high schools around the United States.
- Had watched every single Gene Kelly musical, which led him to becoming "a song and dance man".
- Is good friends with Aimee Mann and Natalie Portman.
- Grew up and went to school with Eric Stoltz and Linus Huffman.
- Named as "Favorite Male Television Performer in a Series" by the People's Choice Awards.
- On an episode of Sala de urgencias (1994), he sang a song made popular by the rock group Styx, "Come Sail Away", when his TV wife gave birth to a baby girl. In real-life, growing up as a teenager, he was a big fan of Styx.
- Attended Santa Barbara Jr. High with Kathleen Wilhoite who co-starred in several episodes of Sala de urgencias (1994) as "Chloe Lewis".
- Is a big fan of South Park (1997).
- (1986 - 88) Graduated from University of Southern California with a BA in drama
- Has a cat named Nitro.
- Anthony's father was of English, Irish, Scottish, and one quarter Spanish-Mexican, ancestry. Anthony's maternal grandfather was German, and Anthony's maternal grandmother was born in China, to German parents.
- Is a big fan of race car driving.
- Named "The Sexiest Man" in a prime-time series [1997].
- Moved to Manhattan, New York, in 2002
- Attended San Marcos High School in Santa Barbara, California and graduated in 1980 (as stated on wall of fame plaque in auditorium).
- As a teenager, he collected James Taylor's and Styx's tapes/records.
- His maternal grandfather, Kem Weber (Karl Emanuel Martin Weber), who was born in Berlin, was a prominent furniture/industrial designer, teacher, art director, and architect, and his maternal great-grandfather, Alfred Forke, was a Sinologist and UC Berkeley professor.
- Has expressed regrets about appearing in Top Gun: Pasión y gloria (1986) because he feels the film contributed to a militaristic and warmongering mindset that he is personally opposed to.
- Was raised in "The Riviera", Santa Barbara's answer to Beverly Hills. His family belonged to the Riviera Country Club.
- He has appeared in two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Picardías estudiantiles (1982) and Top Gun: Pasión y gloria (1986).
- Best known by the public for his starring role as Dr. Mark Greene on [Sala de urgencias (1994)].
- Nominated for best actor by the Viewers for Quality Television.
- At 16, he appeared in dozens of plays
- Nominated as "Best Actor" by Cable Ace for his part in Sexual Healing (2006).
- Honda Civic was his very first car.
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