- She is the first Colombian to be nominated for an Academy Award.
- Became the first actress ever to be nominated for an Academy Award for Best Actress in a Leading Performance that was spoke entirely in Spanish throughout the entirety of the film.
- One of very few actors to receive an Academy Award nomination for their screen debut.
- Took acting classes at a Bogotá (Colombia) theater before getting "discovered" by an anonymous supporter who referred her name to the casting agent for María, llena eres de gracia (2004).
- Reads Spanish-language books because she misses hearing the language as she did when living in Colombia.
- She is the first person born in the 1980s to have received an Academy Award nomination for Best Actress, for María, llena eres de gracia (2004). Natalie Portman is the first person born in the 1980s to have won the award, for El cisne negro (2010).
- Won Best Actress at the 2004 Cartagena Film Festival in her home country Colombia.
- Invited to join AMPAS in 2005.
- Studied advertising at a college in Colombia before moving to New York City around 2003.
- She is one of the few actors to receive an Academy Award nomination for their first ever feature film.
- Was one of People Magazine's "50 Most Beautiful People" in 2005.
- Attended Saint George's School in Bogotá, Colombia.
- Mother is a pathologist.
- Was in New York when she heard on television that she was nominated for Best Performance by an Actress for her role in María, llena eres de gracia (2004).
- Became interested in theater and stage at a very young age.
- Catalina (in 2004), Yalitza Aparicio (for Roma (2018)), and Ariana DeBose (for Amor sin barreras (2021)), are thus far the only actors of Latin American descent born after 1980 to have been nominated for an acting Oscar; Ariana won.
- Is a huge fan of Ang Lee and would love to work with him in the future.
- In the future Catalina would love to work with Pedro Almodóvar and Alejandro Amenábar.
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