It's clear that the external shot of the the building where Ann Romano and her daughters live does not match up with interior set used during the series. The Spanish style windows do not match up with the windows shown inside the apartment, for example.
The family supposedly moves from Logansport,Indiana to Indianapolis at the beginning of the series.
However, the area where they are shown departing is clearly not "Logansport" which is a small city of roughly 20k located in the north-central portion of the state. No major interstates run in or near Logansport and the city is surround by farmland and some low rolling hills.