In a 1987 interview on Sinister Image (1987) Vincent Price revealed that when this remake was released, star Jeff Goldblum wrote him a letter saying, "I hope you like it as much as I liked yours." Price was touched by the letter, he composed a reply and went to see the film, which he described as "wonderful right up to a certain point... it went a little too far."
After watching some of his early films, director Martin Scorsese asked to meet David Cronenberg. Upon meeting him, Scorsese said he looked like a Beverly Hills plastic surgeon. This inspired Cronenberg to give himself a cameo as a doctor.
The line, "I'm saying, I'm an insect who dreamt he was a man and loved it, but now that dream is over, and the insect is awake." is a reference to author Zhuangzi's famous Butterfly Dream story. It's also a reference to Franz Kafka's famous short story, The Metamorphosis.
The scene where Seth and Ronnie are having coffee at the restaurant, and Seth is talking endlessly, was only half scripted when production began. The remainder was written the night before the scene was going to be filmed, as Jeff Goldblum felt that he could add more to the character.
David Cronenberg: [disease POV] Brundle describes his condition from the "disease's" viewpoint, saying its "purpose" or its "want" is to "turn him into something else."