Some of the musical guests on his very popular "The Super Dave Osborne Show " included young drummer Jacob Armen, Banig (Josephine Roberto), Canadian-born singer Veronique Beliveau, Cynthia Belliveau, Sonny Bono, Canadian-born classical guitarist Liona Boyd, Glen Campbell, Kim Carnes, Ray Charles, saxophonist Clarence Clemons, John Davidson, Canadian-born singer Celine Dion, Thelma Houston, young piano player and singer Tony Ford, Canadian-born singer Colin James, Canadian-born singer/comedian Kelita (Kelita Haverland), Canadian-born singer k.d. lang, Jerry Lee Lewis, Melissa Manchester, Bill Medley, Canadian-born singer Sue Medley, Bobby McFerrin, Jerry Reed, Kenny Rogers, Randy Travis, Billy Vera, Dionne Warwick, Canadian-born singer Michelle Wright, Canadian-born singer Lori Yates, the four girl group En Vogue, along with these top Canadian musical groups Blue Rodeo, Candi & The Backbeat, Doug and The Slugs, The Nylons and The Razorbacks.
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Some of the other performers who were featured included Canadian-born classical comedic pianist Mitchell Zeidwig, stuntman Robbie Knievel, ventriloquist Willie Tyler and Lester, ventriloquist Ronn Lucas, ventriloquist Jeff Dunham, sports broadcaster Roy Firestone, tap dancer Savion Glover, juggler Robert Gruenberg, talk show interviewer Larry King, juggler Michel Lauziere, Canadian-born impressionist André-Philippe Gagnon, boxer Evander Holyfield, comedian Steve Allen, Canadian-born comic Jenny Jones, talk show host Regis Philbin, and the Smothers Brothers, whose variety show Bob Einstein got his start writing for.
