This simple story explain very well that we have one life to live as we choose, although sometimes we might doubt about our decision and we should be ready to revise them, as age advances.
This is our journey and we should not be influenced by conventions to choose a "normal" life. Besides, as shown in the film, there is nothing great in living the "normal" life, especially if you feel you are not cut out for it.
Irene chose to inspect luxury hotels for a living and travels most of the time. She could have a stable relationship, proved by the fact that she is very friendly with her ex and meets him regularly, but for the sake of the narrative, we must assume she cannot have it.
Her sister Silvia leads the "normal" life, married with a couple of kids. However, she does not seem ecstatically happy. In fact, she has all the "normal" problems of middle aged people: a boring marriage; growing kids; loosing her attractiveness, etc...
Irene suffers a panic attack following a fleeting connection with another guest at a luxury hotel. The false sense of security a luxury hotel may give is briefly debated, but my personal opinion is that it is still better to sleep in a 5 star hotel than under a bridge - so I am not a fan of the social commentary, but it is a sideline.
This is for me a simple tale about the meaning of life. One should understand that your life has the meaning you give to it and that there is no right or wrong. Good movie, anyway...