- Two years after the untimely death of his first wife, Michelle McNamara, her nonfiction crime book "I'll Be Gone in the Dark" debuted at No. 1 on the New York Times Bestseller List (2018). The introduction and afterword were contributed by author Gillian Flynn and Oswalt respectively.
- Is a huge movie buff, especially of classic and noir films. During a period from the mid to late 1990s, he grew addicted to watching films and would go to the theater almost daily. This is chronicled in his book "Silver Screen Fiend".
- Has one daughter with Michelle McNamara: Alice Rigney Oswalt (born April 15, 2009).
- Attended and graduated from Broad Run High School in Ashburn, Virginia. (1987)
- Has been an outspoken critic of U.S. President Donald Trump. In January 2019, following an intense Twitter feud with one of Trump's supporters, he donated $2,000 to the man's GoFundMe fund created to help cover his medical expenses.
- Was named after World War II hero General George S. Patton.
- Nominated for the 2018 Emmy Award in the Outstanding Writing for a Variety Series category for Patton Oswalt: Annihilation (2017), but lost out to John Mulaney for John Mulaney: Kid Gorgeous at Radio City (2018).
- Recently discovered he's allergic to gluten. He has been diagnosed with clinical depression, which he has engaged through his adult life. He has incorporated these experiences into his comedy routines.
- His comedy special Patton Oswalt: Talking for Clapping (2016) was released on Netflix. (avril 2016)
- Older brother of Matt Oswalt, creator of the Puddin' web series.
- His father's ancestry is English, German, Scottish and Irish. His maternal grandfather, Peter Nicholas Runfola, was of Italian/Sicilian ancestry, and his maternal grandmother, Mary Cecilia Brennan, was of Irish ancestry.
- Received his Bachelor of Arts degree from the College of William & Mary in Williamsburg, Virginia (1991). He later received an honorary degree (Doctor of Arts) from the College of William & Mary (May 2023). Is a member of the Phi Kappa Tau fraternity.
- Confirmed his engagement to actress Meredith Salenger. (juillet 2017)
- Oswald's comedic influences include Jonathan Winters, Richard Pryor, Steve Martin, Sam Kinison, Emo Philips, Bobcat Goldthwait, Blaine Capatch, Jim Goad, Bill Hicks and Louis C.K..
- Like Frank Conniff, who played his onscreen father in Mystery Science Theater 3000: The Return (2017), he is a staunch Democrat. He endorsed Barack Obama for his re-election as president (2012), and Joe Biden for his presidential campaign (2020).
- Is a self-confessed huge fan of Star Trek and has referenced the franchise as Spencer Olchin on his famous sitcom The King of Queens (1998). He has done voice-over work on Star Trek: Picard (2020), and has appeared on Star Trek: Strange New Worlds (2022).
- His favorite movie is the comedy drama Six Pack (1982).
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