- Graduated Phi Beta Kappa from University of Notre Dame, South Bend, Indiana.
- Life partner, and then husband, of actor, screenwriter, producer Dan Bucatinsky. Don and Dan met and became a couple in 1992, and subsequently were legally married in 2008.
- Frequently collaborates with Lisa Kudrow, who, besides being friends with Don, is also the producing partner of Don's husband, Dan Bucatinsky.
- Two children with husband Dan Bucatinsky, one girl named Eliza, and one boy named Jonah.
- Owns a house in Ireland.
- Frequently casts Lisa Kudrow (films and TV), Johnny Galecki (films only), and his husband, Dan Bucatinsky (films and TV) in productions he directs.
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