- When joining the SAG, there already was another "Danny McBride" ('Dirty Dan' McBride), so he added the initial to his professional name. After receiving more and more movie credit he is allowed to go by "Danny McBride" since mid-2008.
- Usually receives writing credit as "Danny R. McBride".
- Once worked as a substitute teacher.
- Was in a relationship with Gia Ruiz for nine years before getting married. They got engaged in their sixth year together.
- Wife's uncle is Cheech Marin.
- Attended film school with longtime friend David Gordon Green.
- McBride's wife, Gia Ruiz, gave birth to their first child, a son named Declan George McBride (Sept. 26, 2011).
- Cousin to Jamie McBride.
- Announced that he and wife Gia Ruiz are expecting a son. (avril 2011)
- Danny's father has English, as well as Scottish and Scots-Irish (Northern Irish), ancestry. Danny's mother has Russian Jewish (from her own paternal grandfather), English, and German ancestry.
- Honeymooned in Bora Bora.
- Grew up in Spotsylvania, Virginia.
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