One of the series most subtle homages to Anime is the casting of several Actors who have appeared in other famous Anime. K.O's actress Stephanie Nadolny played young Goku on Dragon Ball (1995), while Enid's actress Ashly Burch is most famous for voicing Sasha in Shingeki no Kyojin (2013).
During the show's development, Rad's original real name was going to be Radimus.
One of the stickers on KO's binder is the Cartoon Network logo.
Enid, one of the main characters references the anime Naruto In many ways. In one episode, she is seen with a manga that has Naruto and Sasuke on the cover. She also has used versions of jutsu like the Nara clan's shadow jutsus, and the susano'o. She has also been stated to want to learn Genjutsu, one of the 3-4 basic principles in Naruto.