The makeup department and crew had a hard time dealing with the dogs, who kept licking the zombie makeup, blood and meat off of themselves.
Michelle Rodriguez had informed her agent that if anyone ever wrote a script about Resident Evil that she wanted to be a part of it. Her agent duly put her in contact with Paul W.S. Anderson when his screenplay was bought.
(at around 50 mins) One of the most popular scenes in the film - when Alice runs up a wall and flings round to kick a zombie dog in the head - took 3 months of training for Milla Jovovich.
Milla Jovovich did all of her own stunts except the pipe jump in the sewer scene. A stunt double was used because her agent thought she would get strangled by the hanging wires.
Jason Isaacs: The narrator at the opening of the film and the voice of the scientist who wants to re-open the hive.