Several scenes of the children training at Manticore were edited for the opening scenes of Tueur à gages (2007), which has a similar theme of genetically enhanced children being trained as assassins and a protagonist (Agent 47) with a barcode on the back of his neck.
The character 'Max Guevara' was ranked #17 in TV Guide's list of the "25 Greatest Sci-Fi Legends" (1 August 2004 issue).
Co-producer Kenneth Biller said in a Season 2 DVD interview that their filming location, Vancouver, would not allow them to "trash" a nice neighborhood. Hence, Terminal City had to be built from scratch.
The often-referenced S1W's are a likely reference to the S1W's of rap group Public Enemy. Public Enemy's front man 'Chuck D.' helped write the main theme music for the show.