A fan loved the dress Gabrielle (Eva Longoria) wore in the pilot so much, she wrote to the producers asking the name of the designer, and if he could design her a prom dress. The producers instead sent her the actual gown, and she wore it to her prom.
Originally started off as a comedy pilot, and was rejected by every network, including Lifetime and HBO. ABC expressed an interest, and it was retooled to its current format of a dark comedy and drama.
After spending four seasons playing Wilhelmina Slater on Ugly Betty (2006), Vanessa Williams was still under contract with ABC for two more years. Because of this, the part of Renee Perry was created for her.
Marcia Cross originally tried for the part of Mary Alice Young, but was cast as Bree Van De Kamp. Nicollette Sheridan tried for the part of Bree Van De Kamp, but was cast as Edie Britt.
Teri Hatcher is the first person to win the Screen Actors Guild Award for Outstanding Performance by an Actress in a Comedy Series, for a show that had not yet completed its first season.