The only characters from the canon of Mickey and friends that do not appear in this show are Scrooge McDuck, Horace Horsecollar, Fifi, and Huey, Dewey and Louie.
In the show, Mickey Mouse often says "Hot dog!" as an exclamation. This is a callback to the first time Mickey ever spoke in a cartoon. The short was called The Karnival Kid (1929) and the first words that Mickey says are "Hot dog!" When Mickey says "Meeshka Mooshka" it's a reference to The Mickey Mouse Club (1955).
This is Disney Television Animation's first computer-animated series. This is also the first time Mickey and Minnie's ears swivel in CGI when their heads turn like they do in 2D animation.
All the characters remained in their traditional outfits from previous Mickey Mouse movies and TV shows except for Minnie Mouse, Daisy Duck, Pete and Clarabelle.
Mickey Mouse was voiced by Wayne Allwine until Season 4 due to his passing in 2009. His remaining voice recordings were being used until 2012. In 2012, Season 4 was in production while Bret Iwan took place for his role recording Mickey's new lines.