When asked about his most difficult scene, Jeremy Renner revealed that it was the motorcycle ride with Rachel Weisz behind him in Manila, because he was responsible for the two of them. At the press conference of the film, Weisz was asked about this particular stunt, "How was it to ride on a motorcycle through Manila with Jeremy Renner?" and she said that "It was really terrifying! Jeremy never told me when we were in Manila, but that was the scariest stunt for him because he was responsible for my life. He didn't tell me that in Manila, thank god, because I would have been like, 'Oh, my god!' I just had to surrender and hold on. I didn't have to act. It just was terrifying".
Daniel Craig visited his wife Rachel Weisz during their shoot in Manila. Producer Frank Marshall was glad to see them together, saying: "It was pretty cool to have James Bond on the 'Bourne' set with Aaron Cross. We had a great time. It was really fun."
Originally a fourth installment for Jason Bourne was planned. However, Matt Damon and Paul Greengrass didn't like the script, Paul Greengrass didn't want to return as director, and Damon would've returned if only Paul would return as director. After that, Tony Gilroy would re-work the script into a Bourne spin-off, now released as "The Bourne Legacy".
This movie, The Bourne Supremacy and The Bourne Ultimatum are all set in 2004.
Matt Damon told The Playlist he could not see his character and the character played by Jeremy Renner being in a movie together.