Producers for The Boys (2019) reached out to Patrick Schwarzenegger after meeting him when he auditioned for Homelander in the original series. He wasn't allowed to read any scripts until he was officially cast.
Jaz Sinclair and Chance Perdomo both appeared in Chilling Adventures of Sabrina (2018). Both played prominent characters, Sinclair as Sabrina's best friend Roz and Perdomo as Sabrina's cousin Ambrose.
Filming began at the University of Toronto Mississauga campus in May 2022 and the Claireville Conservation Area, Brampton in July, intended for an October wrap, under the working title of "The Boys Presents: Varsity." Other filming locations include Sobeys Stadium, and the Stardust Drive-In Movie Theater. In July 2022, it was announced that the series would officially be titled "Gen V." In September 2022, members of the cast announced on social media that production had wrapped.
In October 2023, less than a month after its premiere, it was renewed for a second season.