Co-director Richard Glatzer could not speak due to ALS. He directed the film using a text to speech app on an iPad. Julianne Moore and Kristen Stewart dedicated their "Ice Bucket Challenge" to Glatzer.
Julianne Moore suggested the role of Dr. John Howland to Alec Baldwin because they wanted to work together again.
Directors Wash Westmoreland and Richard Glatzer were unable to attend the Oscars to see Julianne Moore win because Glatzer's ALS had deteriorated significantly.
For her portrayal of Alice Julianne Moore won the Quintuple Crown of Best Actress (winning the Golden Globe Award, Screen Actors Guild Award, Critics' Choice Award, BAFTA Award, and Academy Award). This marks the second consecutive time that an actress winner of the Quintuple Crown was married to Alec Baldwin on screen. The previous winner was Cate Blanchett, who won for her role as Jasmine in Jasmine French (2013). This also marks the second time in a row (for all the awards), that the actress won for a movie that was not nominated for Best Picture. Both characters also had their names in their respective movie's title.